Individuals with Down syndrome (DS) have an increasing age-related prevalence of Alzheimer’s disease (AD). In DS, the triplication of amyloid precursor protein on chromosome 21 contributes to a life-long accumulation of brain amyloid. Dementia increases with age to over 75% prevalence after age 65 years.
In non-demented adults with DS, PET studies have shown increased amyloid uptake. However, the relationship between amyloid uptake and cognitive decline in DS has not been determined. This study compares brain amyloid distribution by consensus diagnosis in patients with DS using 18F-AV-45 PET.
The talk is available at the AAIC Learning Center and unfortunately is not free.
Or you can view the poster directly: DownsADDSPET_AAIC_2019