Welcome to the Hughes Lab!

Our research is focused on the processes of blood vessel development and angiogenesis and how these relate to normal wound healing and tumor growth. In particular, we wish to identify the genes that regulate the specific phenotypes adopted by angiogenic endothelial cells (EC), such as tip cells, tube-forming cells, and anastomosing cells, as these may provide unique drug targets for anti-angiogenic therapy. We have developed several in vitro and in vivo tools that model different aspects of these processes.

We are collaborating with colleagues in Biomedical Engineering to create vascularized tissues that can be used for transplants or in the development of sophisticated 3D tissues suitable for drug screening. Microphysiological systems we are currently working on include heart, liver, pancreas, blood brain barrier, skin, and bone marrow, as well as tumors such as colon, breast, ovarian and glioblastoma.

We also have a project investigating the molecular mechanisms underlying Hereditary Hemorrhagic Telangiectasia (HHT) and Sturge-Weber Syndrome.

Career Opportunities (2/16/23)

Postdoctoral Scholar Positions in Microphysiological Systems (“Tissue Chips”) Two NIH-funded postdoctoral positions are available to work on the development of body-on-chip devices in the areas of Cancer Biology and Blood-Brain Barrier. The ideal candidate will have experience in cell culture, vascular biology, bioengineering (including COMSOL modeling), and microfluidic systems. Prior knowledge in the areas of cancer or BBB would be an advantage, however, candidates with any combination of the above should consider applying.
Initial appointment is for one year with an anticipated extension to 3 years pending satisfactory performance and funding. Salary will be commensurate with experience and University guidelines.

Qualified candidates should send curriculum vitae, a cover letter outlining research experience and interests, and the names, phone numbers and e-mail addresses of three references to the following on-line recruitment URL: https://recruit.ap.uci.edu/JPF08095

For more information about this position, please contact Dr. Christopher C. Hughes at cchughes@uci.edu