Welcome to the Hughes Lab!
Our research is focused on the processes of blood vessel development and angiogenesis and how these relate to normal wound healing and tumor growth. In particular, we wish to identify the genes that regulate the specific phenotypes adopted by angiogenic endothelial cells (EC), such as tip cells, tube-forming cells, and anastomosing cells, as these may provide unique drug targets for anti-angiogenic therapy. We have developed several in vitro and in vivo tools that model different aspects of these processes.
We are collaborating with colleagues in Biomedical Engineering to create vascularized tissues that can be used for transplants or in the development of sophisticated 3D tissues suitable for drug screening. Microphysiological systems we are currently working on include heart, liver, pancreas, blood brain barrier, skin, and bone marrow, as well as tumors such as colon, breast, ovarian and glioblastoma.
We also have a project investigating the molecular mechanisms underlying Hereditary Hemorrhagic Telangiectasia (HHT) and Sturge-Weber Syndrome.