2021
Subramanian, V.S., Teafatiller, T., Agrawal, A., Kitazawa, M. and Marchant, J.S. (2021) “Effect of lipopolysaccharide and TNFα on neuronal ascorbic acid uptake” Mediators of Inflammation 2021:4157132. PMID: 34285658; PMCID: PMC8275400.
Hsu, H.W., Rodriguez-Ortiz, C.J., Zumkehr, J., and Kitazawa, M. (2021) “Inflammatory cytokine, IL-1β downregulates endothelial LRP1 via microRNA-mediated gene silencing” Neuroscience 453:69-80.
Baglietto-Vargas, D., Cai, L., Martini, A.C., Trujillo-Estrada, L., Forner, S., Swarup, V., Nguyen, M.M.T., Huynh, K.D., Jiang, S., Kramar, E.A., Nunez-Diaz, C., Balderrama-Gutierrez, G., Garcia, F., Childs, J., Rodriguez-Ortiz, C.J., Kitazawa, M., Shahnawaz, M., Matheos, D.P., Ma, X., Cunha, C., Ager, R., Soto, C., Gutierrez, A., Moreno-Gonzalez, I., MacGregor, G.R., Green, K.N., Wood, M.A., Mortazavi, A., Tenner, A.J., and LaFerla, F.M. “Human wildtype Abeta knock-in mice as a basis to study sporadic Alzheimer’s disease” Nat. Comm. 12:2421.
2020
Martini, A.C., Gomez-Arboledas, A., Forner, S., Rodriguez-Ortiz, C.J., McQuade, A., Danhash, E., Phan, J., Javonillo, D., Ha, J.V., Tram, M., Trujillo-Estrada, L., Cunha, C., Ager, R., Davila, J.C., Kitazawa, M., Blurton-Jones, M., Gutierrez, A., Baglietto-Vargas, D., Medeiros, R., and LaFerla F.M. (2020) “Amyloid-beta impairs TOM1-mediated IL-1R1 signaling” Proc. Nat. Acad. Sci. 116(42):21198-21206. PMCID: PMC680033
Lim, S.L., Tran, D.N., Kieu, Z., Chen, C., Villanueva, E., Ghiaar, S., Gallup, V., Zumkehr, J., Cribbs, D.H., Rodriguez-Ortiz, C.J., and Kitazawa, M. (2020) “Genetic ablation of hematopoietic cell kinase accelerates Alzheimer’s disease-like neuropathology in Tg2576 mice” Mol. Neurobiol. 57(5):2447-2460. PMCID:PMC7187907
Lim, S.L., Hsu, H.W. Rodriguez-Ortiz, C.J., Wu, J., Zumkehr, J., Kilian, J., Vidal, J., Ayata, P., and Kitazawa, M. (2020) “Chronic copper exposure directs microglia towards degenerative expression signatures in wild-type and J20 mouse model of Alzheimer’s disease” J. Trace Elem. in Med. Biol.62:126578. doi: 10.1016/j.jtemb.2020.126578
Hsu, H.W., Rodriguez-Ortiz, C.J., Zumkehr, J., and Kitazawa, M. (2020) “Inflammatory cytokine, IL-1β downregulates endothelial LRP1 via microRNA-mediated gene silencing” Neuroscience 453:69-80
2019
Huat, T.J., Camats-Perna, J., Newcombe, E.A., Valmas, N., Kitazawa, M., and Medeiros, R. (2019) Metal toxicity links to Alzheimer’s disease and neuroinflammation. J. Mol. Biol. 431(9):1843-1868. PMCID:PMC6475603
Hsu, H.W., Rodriguez-Ortiz, C.J., Lim, S.L., Zumkehr, J., Kilian, J.G., Vidal, J., and Kitazawa, M. (2019) Copper-induced upregulation of microRNAs directs the suppression of endothelial LRP1 in Alzheimer’s disease model. Toxicol. Sci. 170(1):144-156. PMCID:PMC6592190
Rodriguez-Ortiz, C.J., Prieto, G.A., Martini, A.C., Forner, S., Trujillo-Estrada, L., LaFerla, F.M., Baglietto-Vargas, D., Cotman, C.W., and Kitazawa, M. (2020) “miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease” Aging Cell 19(3):e13118. PMCID:PMC7059142
Forner, S., Martini, A.C., Prieto, G.A., Dang., C.T., Rodriguez-Ortiz, C.J., Reyes-Ruiz, J.M., Trujillo-Estrada, L., Cunha, C., Andrews, E.J., Phan, J., Ha., J.V., Chang, A.V.Z.D., Levites, Y., Cruz, P.E., Ager, R., Medeiros, R., Kitazawa, M., Glabe, C.G., Cotman, C.W., Golde, T., Baglietto-Vargas, D., and LaFerla, F.M. (2019) “Intra- and extracellular amyloid-beta overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus” Sci. Rep. 9(1):15936. PMCID:PMC6828807
2018
Bagliett-Vargas, D., Prieto, A.G., Limon, A., Forner, S., Rodriguez-Ortiz, C.J., Ikemura, K., da Cunha, C., Agar, R.A., Medeiros, R., Trujillo-Estrada, L., Martini, A.C., Kitazawa, M., Davila, J.C., Cotman, C.W., Gutierrez, A., and LaFerla F.M. (2018) Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease. Aging Cell Jun 6:e12791. PMCID: PMC6052400
Zumkehr, J., Rodriguez-Ortiz, C.J., Medeiros, R., and Kitazawa, M. (2018) Inflammatory cytokine, IL-1β, regulates glial glutamate transporter via microRNA-181a in vitro. J. Alz. Dis. 63(3):965-975. PMID: 29710703
Hsu, H.W., Bondy, S.C., and Kitazawa, M. (2018) Environmental and dietary exposure to copper and its cellular mechanisms linking to Alzheimer’s disease. Toxicol. Sci. 163(2):338-345. PMID 29409005
Kilian, J.G. and Kitazawa, M. (2018) The emerging risk of exposure to air pollution on cognitive decline and Alzheimer’s disease – Evidence from epidemiological and animal studies. Biomedical J. 41(3):141-162.
Lim, S.L., Tran, D.N., Zumkehr, J., Chen, C., Ghiaar, S., Kieu, Z., Villanueva, E., Gallup, V., Rodriguez-Ortiz, C.J., and Kitazawa, M. (2018) Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer’s disease-like neuropathology. Glia doi: 10.1002/glia.23522. PMCID:PMC6645690
2017
Kilian, J.G., Hsu, H.W., Mata, K., Wolf, F.W., and Kitazawa, M. (2017) Astrocyte transport of glutamate and neuronal activity reciprocally modulate tau pathology in Drosophila. Neuroscience 348:191-200. PMID: 28215745
Nakazono, T, Lam, T.N., Patel, A.Y., Kitazawa, M., Saito, T., Saido, T.C., and Igarashi, K.M. (2017) Impaired in vivo gamma oscillations in the medial entorhinal cortex of knock-in Alzheimer model. Front. Systems Neurosci. 11:48. PMID: 28713250
2016
Kitazawa, M., Hsu, H.W., and Medeiros, R. (2016) Copper exposure perturbs brain inflammatory responses and impairs clearance of amyloid-beta. Toxicol. Sci. 152(1):194-204.
Rodriguez-Ortiz, C.J., Flores, J.C., Valenzuela, J., Rodriguez, G.J., Zumkehr, J., and Kitazawa, M. (2016) The myoblast C2C12 transfected with mutant valosin-containing protein (VCP) exhibits resolution deficiencies upon oxidative stress. Am. J. Pathol. 186(6):1623-1634.
2015
Lim, S.L., Rodriguez-Ortiz, C.J., and Kitazawa, M. (2015) Infection, systemic inflammation and Alzheimer’s disease. Microbes and Infection 17(8):549-556. PMID: 25912134
Zumkehr, J., Rodriguez-Ortiz, C.J., Cheng, D., Kieu, Z., Wai, T., Hawkins, C., Kilian, J., Lim, S.L., Medeiros, R., and Kitazawa, M. (2015) Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer’s disease. Neurobiol. Aging. 36(7):2260-2271. PMID: 25964214
Dunn, H.C., Ager, R.R., Baglietto-Vargas, D., Cheng, D., Kitazawa, M., Cribbs, D.H., and Medeiros, R. (2015) Restoration of lipoxin A4 signaling reduces Alzheimer’s disease-like pathology in the 3xTg-AD mouse model. J. Alz. Dis. 43(3):893-903. PMID: 25125468 PMCID: PMC4319708
2014
Rodriguez-Ortiz, C.J., Baglietto-Bargas, D., Martinez-Coria, H., LaFerla, F.M. and Kitazawa, M. (2014) Up-regulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice. J. Alz. Dis. Accepted.
Elmore M.R., Najafi, A.R., Koike, M.A., Dagher, N.N., Spangenberg, E.E., Rice, R.A., Kitazawa, M., Matusow, B., Nguyen, H., West, B.L. and Green, K.N. (2014) Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in adult brain. Neuron 82(2):380-397. PMID: 24742461
Medeiros, R., Castello, N.A., Cheng, D., Kitazawa, M., Baglietto-Vargas, D., Green, K.N. and LaFerla, F.M. (2014) α7 nicotinic receptor agonist enhances cognition in aged 3xTG-AD mice with robust plaques and tangles. Am. J. Pathol. 184:520-529. PMID: 24269557
Bagliett-Vargas, D., Kitazawa, M., Le, E.J., Estrada-Hernandez, T., Rodriguez-Ortiz, C.J., Medeiros, R., Green, K.N. and LaFerla, F.M. (2014) Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol. Dis. 62:407-415. PMID: 24176788
2013
Rodriguez-Ortiz, C.J., Hoshino, H., Cheng, D., Liu-Yescevitz, L., Blurton-Jones, M., Wolozin, B., LaFerla, F.M. and Kitazawa, M. (2013) Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am. J. Pathol. 183(2):504-515. PMID: 23747512, PMCID: PMC3730785
Medeiros, R., Kitazawa, M., Passos, G. F., Baglietto-Vargas, D., Cheng, D., Cribbs, D. H., and LaFerla, F. M. (2013) Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. Am. J. Pathol. 182(5):1780-1789. PMID 23506847
2012
Nalbandian A., Llewellyn K. J., Kitazawa, M., Hon, Y., Badadani, M., Ewards, R., Nguyen, C., Mukherjee, J., Watts, J., Mozaffar, T., Weiss, J., and Kimonis, V. E. (2012) The homozygous VCP(R155H/R155H) mouse model exhibits accelerated VCP disease-associated pathology. PLoS One 7(9):e46308. PMID: 23029473, PMCID: PMC3460820
Medeiros, R., Kitazawa, M., Cheng, D., Chabrier, M., Baglietto-Vargas, D., Moeller, A., Kling, A., Green, K. N., and LaFerla, F. M. (2012) Calpain inhibitor A-705253 mitigates Alzheimer disease-like pathology and cognitive decline in aged 3xTg-AD mice. Am. J. Pathol. 181(2):616-625. PMID: 22688056
Kitazawa, M., Medeiros, R., and LaFerla, F. M. (2012) Transgenic mouse models of Alzheimer disease: Developing a better model as a tool for therapeutic interventions. J. Curr. Pharmaceut. Design 18(8):1131-1147. PMID: 22288400
2011
*Morroni, F., *Kitazawa, M., Drago, D., Cheng, D., Medeiros, R., and LaFerla, F. M. (2011) Physical or intellectual rehabilitation induces neurogenesis and synaptogenesis following neuronal injury in an inducible mouse model. J. Brain Behav. Sci. 1(4):199-209. (*these authors contributed equally to this work)
Kitazawa, M., Cheng, D., Tsukamoto, M., Koike, M., Wes, P., Vasilevko, V., Cribbs, D. H., and LaFerla, F. M. (2011) Blocking interleukin-1 signaling rescues cognition, attenuates tau pathology and restores neuronal beta-catenin pathway in an Alzheimer’s disease model. J. Immunol. 187(12):6539-6549. PMID: 22095718
Medeiros, R., Kitazawa, M., Caccamo, A., Baglietto-Vargas, D., Estrada, T., Fisher A., and LaFerla, F. M. (2011) Loss of muscarinic M1 receptor exacerbates Alzheimer disease-like pathology in 3xTgAD and Tg-SwDI mice. Am. J. Pathol. 179(2):980-991. PMID: 21704011, PMCID: PMC3157199
Koike, M. A., Garcia, F. G., Kitazawa, M., Green, K. N., and LaFerla F. M. (2011) Transient cerebral ischemia induces long-term alterations in phosphorylated APP and tau aggregates. Neurosci. Lett. 495(1):55-59. PMID: 21419194, PMCID: PMC3099741
*Sy, M., *Kitazawa, M., Medeiros, R., Whitman, L., Cheng, D., Lane, T. E., and LaFerla, F. M. (2011) Inflammation induced by infection potentiates tau pathology in transgenic mice. Am. J. Pathol. 178(6):2811-2822. (*these authors contributed equally to this work) PMID: 21531375, PMCID: PMC3124234
2010
Badadani, M., Watts, G. D., Vesa, J., Nalbandian, A., Kitazawa, M., Su, H., Tanaja, J., Dec, E., Wallace, D. C., Mukherjee, J., Caiozzo, V., Warman, M., and Kimonis, V. E. (2010) VCP associated inclusion body myopathy and Paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One 5(10):e13183. PMID: 20957154, PMCID: PMC2950155
Hasegawa, T., Mikoda, N., Kitazawa, M., and LaFerla, F.M. (2010) Treatment of Alzheimer’s disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS One 5(1):e8593. PMID: 20098691, PMCID: PMC2808336
Martinez-Coria, H., Green, K. N., Billings, L. M., Kitazawa, M., Bannerjee, P., and LaFerla, F. M. (2010) Memantine as a pathology and cognitive modifying therapeutic for Alzheimer’s disease. Am. J. Pathol. 176(2):870-880. PMID: 20042680, PMCID: PMC2808092
2009
Blurton-Jones, M., Kitazawa, M., Martinez-Coria, H., Muller, F. J., Loring, J. F., Poon, W. W., Green, K., N., and LaFerla, F. M. (2009) Neural stem cells rescue cognition and increase synaptic density in Alzheimer disease mice via a neurotrophic mechanism. Proc. Nat. Acad. Sci. U.S.A. 106(32):13594-13599. PMID: 19633196, PMCID: PMC2715325
Kitazawa, M., Vasilevko, V., Cribbs, D. H., and LaFerla, F. M. (2009) Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model. J. Neurosci. 29(19):6132-6141. PMID: 19439591, PMCID: PMC3049190
Kitazawa, M., Cheng, D., and LaFerla, F. M. (2009) Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J. Neurochem. 108(6):1550-1560. PMID: 19183260
2008
Shtifman, A., Ward, C. W., Laver, D. R., Banister, M. L., Lopez, J. R., Kitazawa, M., LaFerla, F. M., Ikemoto, N., and Querfurth, H. W. (2008) Amyloid-beta protein impairs Ca2+ release and contractility in skeletal muscle from inclusion body myositis mice. Neurobiol. Aging 31(12):2080-2090. PMID: 19108934, PMCID: PMC2901770
Kanthasamy, A. G., Kitazawa, M., Yang, Y., Anantharam, V., and Kanthasamy, A. (2008) Environmental neurotoxic chemical induces apoptosis in mesencephalic dopaminergic neuronal cells via caspase-3-dependent proteolytic activation of protein kinase Cdelta: Implications for molecular mechanisms of dopaminergic degeneration in Parkinson’s disease. Mol. Brain 1(1):12. PMID: 18945348
Kitazawa, M., Trinh, D. N., and LaFerla, F. M. (2008) Inflammation induces tau pathology in inclusion body myositis model via GSK-3ß. Ann. Neurol. 64(1):15-24. PMID: 18318434
2007
Yamasaki, T. R., Blurton-Jones, M., Morrissette, D. A., Kitazawa, M., Odd, S., and LaFerla, F. M. (2007) Neural stem cells improve memory in an inducible mouse model of neuronal loss. J. Neurosci. 27(43):11925-11933. PMID: 17978032
2006
Oddo, S., Vasilevko, V., Caccamo, A., Kitazawa, M., Cribbs, D. H., and LaFerla, F. M. (2006) Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J. Biol. Chem. 281(51):39413-39423. PMID: 17056594
Kitazawa, M., Green, K. N., Caccamo, A., and LaFerla, F. M. (2006) Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. Am. J. Pathol. 168(6):1986-1997. PMID: 16723713, PMCID: PMC1606633
*Sugarman, M. C., *Kitazawa, M., Baker, M., Caiozzo, V. J., Querfurth, H. W., and LaFerla, F. M. (2006) Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model. Neurobiol. Aging. 27(3):423-432. (*these authors contributed equally to this work) PMID: 15950323
2005
LaFerla, F. M. and Kitazawa, M. (2005) Antipodal Effects of p25 on synaptic plasticity, learning and memory – too much of a good thing is bad. Neuron 48:711-712. PMID: 16337907
Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., and LaFerla, F. M. (2005) LPS-induced inflammation exacerbates tau pathology by a cdk5-mediated pathway in a transgenic model of Alzheimer’s disease. J. Neurosci.25(39):8843-8853. PMID: 16192374
Latchoumycandane, C., Anantharam, V., Kitazawa, M., Yang, Y., Kanthasamy, A., and Kanthasamy, A. G. (2005) Protein Kinase C Delta (PKCd) is a key downstream mediator of manganese-induced apoptosis in dopaminergic Neuronal Cells. J. Pharmacol. Exp. Ther.313(1):46-55. PMID: 15608081
Kitazawa, M., Anantharam, V., Yang, Y., Hirata, Y., Kanthasamy, A., and Kanthasamy, A. G. (2005) Activation of protein kinase Cd by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2. Biochem. Pharmacol.69(1):133-146. PMID: 15588722
Kanthasamy, A. G., Kitazawa, M., Kanthasamy, A., and Anantharam, V. (2005) Dieldrin-induced neurotoxicity: relevance to Parkinson’s disease pathogenesis. Neurotoxicology26(4):701-719. PMID: 16112328
2004
Anantharam, V., Kitazawa, M., Latchoumycandane, C., Kanthasamy, A., and Kanthasamy, A. G. (2004) Blockade of PKCd proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese (MMT)-induced apoptotic cell death. Annals. N.Y. Acad. Sci. 1035:271-289. PMID: 15681813
Kitazawa, M., Yamasaki, T. R., and LaFerla, F. M. (2004) Microglia as a potential bridge between amyloid-beta and tau. Annals. N.Y. Acad. Sci.1035:85-103. PMID: 15681802
Tseng, B. P., Kitazawa, M., and LaFerla, F. M. (2004) Amyloid-beta: The inside story. Curr. Alzheimer Res.1(4):231-239. PMID: 15975052
Kitazawa, M., Anantharam, V., Kanthasamy, A., and Kanthasamy, A. G. (2004) Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Neurotoxicology 25(4):589-598. PMID: 15183012
2003
Oddo, S., Caccamo, A., Kitazawa, M., Tseng, B., and LaFerla, F. M. (2003) Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer’s disease. Neurobiol. Aging 24:1063-1070. PMID: 14643377
Kanthasamy, A. G., Kitazawa, M., Kaul, S., Yang, Y., Lahiri, D. K., Anantharam, V. and Kanthasamy, A. (2003) Proteolytic activation of proapoptotic kinase PKC-delta is regulated by overexpression of Bcl-2: implication for oxidative stress and environmental factors of Parkinson’s disease. Annals. N.Y. Acad. Sci. 1010:683-686. PMID: 15033812
Kanthasamy, A. G., Kitazawa, M., Kanthasamy, A., Anantharam, V. (2003) Role of proteolytic activation of protein kinase C delta (PKCd) in oxidative stress-induced apoptosis. Antioxidant and redox signaling5(5):609-620. PMID: 14580317
Kaul, S., Kanthasamy, A., Kitazawa, M., Anantharam, V., and Kanthasamy, A. G. (2003) Caspase-3-dependent proteolytic activation of protein kinase Cd mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. Eur. J. Neurosci. 18(6):1387-1401. PMID: 14511319
Kitazawa, M., Anantharam, V., and Kanthasamy, A. G. (2003) Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cd in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience 119(4):945-964. PMID: 12831855
2002
Kitazawa, M., Wagner, J. R., Kirby, M. L., Anantharam, V. and Kanthasamy, A. G. (2002) Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl (MMT). J. Pharm. Exp. Ther.302(1):26-35. PMID: 12065696
Anantharam, V., Kitazawa, M., Wagner, J. R., Kaul, S. and Kanthasamy, A. G. (2002) Caspase-3-dependent proteolytic cleavage of protein kinase Cd is essential for oxidative stress-mediated dopaminergic cell death following exposure to methylcyclopentadienyl manganese tricarbonyl (MMT). J. Neurosci. 22(5):1738-1751. PMID: 11880503
Kanthasamy, A., Kitazawa, M., Kaul, S., Anantharam, V. and Kanthasamy, A. G. (2002) A novel oxidative stress-dependent apoptotic pathway in pesticide-induced dopaminergic degeneration: relevance to environmental factors and Parkinson’s disease. J. Neurochem.81 (Suppl.), 76.