Publications
V. Meli, A. Rowley, P. Veerasubramanian, S. Heedy, W. Liu*, S.-W. Wang*. “Modulation of Stiffness-Dependent Macrophage Inflammatory Responses by Collagen Deposition.” ACS Biomat. Sci. & Eng.. 2024. 10:2212-2223.
A. Ramirez, J. Felgner, A. Jain, S. Jan, T.J. Albin, A.J. Badten, A.E. Gregory, R. Nakajima, A. Jasinskas, P.L. Felgner, A.M. Burkhardt, D.H. Davies, S.-W. Wang. “Engineering Protein Nanoparticles Functionalized with an Immunodominant Coxiella burnetii Antigen to Generate a Q Fever Vaccine.” Bioconj. Chem.. 2023. 34:1653-1666.
A.J. Badten*, A. Ramirez*, J.E. Hernandez-Davies, T.J. Albin, A. Jain, R. Nakajima, J. Felgner, D.H. Davies#, S.-W. Wang#. “Protein Nanoparticle-Mediated Delivery of Recombinant Influenza Hemagglutinin Enhances Immunogenicity and Breadth of the Antibody Response.” ACS Infectious Diseases. 2023. 9:239-252. *Equal first-author contributors.
N. Butkovich, J.A. Tucker, A. Ramirez, E. Li, V.S. Meli, E.L. Nelson, S.-W. Wang. “Nanoparticle vaccines can be designed to induce pDC support of mDCs for increased antigen display.” Biomaterials Science. 2023. DOI:10.1039/ d2bm01132h.
E. Li, C.K. Brennan, A. Ramirez, J.A. Tucker, N. Butkovich, V.S. Meli, A.A. Ionkina, E.L. Nelson, J.A. Prescher, S.-W. Wang. “Macromolecular Assembly of Bioluminescent Protein Nanoparticles for Enhanced Imaging.” Material Today Bio. 2022. 17:100455. https://doi.org/10.1016/j.mtbio.2022.100455.
S. Heedy, J.J. Pineda, V.S. Meli, S.-W. Wang, A.F. Yee. “Nanopillar Templating Augments the Stiffness and Strength in Biopolymer Films.” ACS Nano. 2022. 16(2):3311-3322. https://doi.org/10.1021/acsnano.1c11378.
N. Butkovich*, E. Li*, A. Ramirez*, A.M. Burkhardt, S.-W. Wang. “Advancements in Protein Nanoparticle Vaccine Platforms to Combat Infectious Disease.” WIREs Nanomedicine and Nanobiotechnology, 2021; e168. doi: 10.1002/wnan.1681. *Equal first-author contributors
M. Neek, J.A. Tucker, N. Butkovich, E.L. Nelson, S.-W. Wang. “An Antigen-Delivery Protein Nanoparticle Combined with Anti-PD-1 Checkpoint Inhibitor Has Curative Efficacy in an Aggressive Melanoma Model.” Advanced Therapeutics, 2020. doi: 10.1002/adtp.202000122
A.T. Rowley, V.S. Meli, N.J. Wu-Woods, E.Y. Chen, W.F. Liu*, S.-W. Wang*. “Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation.” Frontiers in Bioengineering & Biotechnology. 2020. 8:747. doi: 10.3389/fbioe.2020.00747. *Co-corresponding authors
K.R. Fruehauf, T.I. Kim, E.L. Nelson, J.P. Patterson, S.-W. Wang*, K.J. Shea*. “Metabolite Responsive Nanoparticle-Protein Complex.” Biomacromolecules. 2019. 20:2703-2712. DOI: 10.1021/acs.biomac.9b00470.
A.T. Rowley, R. Nagalla, S.-W. Wang*, W.F. Liu*, “Extracellular-matrix based strategies for immunomodulatory biomaterials engineering.” Advanced Healthcare Materials. 2019. Feb 4:e1801578. DOI: 10.1002/adhm.201801578. Invited review.
M. Neek, T.I. Kim, S.-W. Wang. “Protein-Based Nanoparticles in Cancer Vaccine Development.” Nanomedicine: Nanotechnology, Biology, and Medicine. 2019. 15:164-174. DOI: https://doi.org/10.1016/j.nano.2018.09.004
R.A. Que, D.R. Crakes, F. Abdulhadi, C.-H. Niu, N.A. Da Silva, S.-W. Wang. “Tailoring Collagen to Engineer the Cellular Microenvironment.” Biotechnology Journal. 2018. 1800140 DOI: 10.1002/biot.201800140
R.A. Que, J. Arulmoli, N.A. Da Silva, L.A. Flanagan, S.-W. Wang. “Recombinant collagen scaffolds as substrates for human neural stem/progenitor cells.” J. Biomed. Mat. Res. A, 2018. 106:1363-1372. DOI: 10.1002/jbm.a.36343
M. Neek, J.A. Tucker, T.I. Kim, N.M. Molino, E.L. Nelson, S.-W. Wang. “Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses.” Biomaterials, 2018, 156:194-203. DOI: https://doi.org/10.1016/j.biomaterials.2017.11.022
Y.K. Kim, S.-H. Chu, J.Y. Hsieh, C.M. Kamoku, A.J. Tenner, W.F. Liu, S.-W. Wang. “Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses.” Advanced Healthcare Materials, 2017. 6:1700707. DOI: 10.1002/adhm.201700707
N.M. Molino*, M. Neek*, J.A. Tucker, E.L. Nelson, and S.-W. Wang. “Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells.” ACS Biomaterials Science and Engineering,2017, 3: 496–501. DOI: 10.1021/acsbiomaterials.7b00148
B. Chou, P. Mirau. T. Jiang., S.-W. Wang, K.J. Shea. “Hydrogel Affinity Reagents for Molecules with Lipid-Like Domains.” Biomacromolecules, 2016. DOI: 10.1021/acs.biomac.6b00296.
N.M. Molino, M. Neek, J.A. Tucker, E.L. Nelson, S.-W. Wang. “Viral-Mimicking Protein Nanoparticle Vaccine for Eliciting Anti-tumor Responses.” Biomaterials. 86:83-91 (2016).
Q. Chen, Q. Sun, N.M. Molino, S.-W. Wang, E.T. Boder, W. Chen. “Sortase-A mediated Multi-functionalization of Protein Nanoparticles.” Chemical Communications. 51:12107-12110 (2015).
R. Que, S.W.P. Chan, A. Jabaiah, R.H. Lathrop, N.A. Da Silva, and S.-W. Wang. “Tuning Cellular Response by Modular Design of Bioactive Domains in Collagen.” Biomaterials. 53:309-317 (2015).
R. Que, A. Mohraz, N. Da Silva, S.-W. Wang. “Expanding Functionality of Recombinant Human Collagen Through Engineered Non-Native Cysteines.” Biomacromolecules. 15:3540-3549 (2014). DOI 10.1021/bm500735d.
Y.K. Kim, R. Que, S.-W. Wang, W. Liu. “Modification of Biomaterials with a Self Protein Inhibits the Macrophage Response.” Advanced Healthcare Materials. 3(7):989-994 (2014).
N.M. Molino, S.-W. Wang. “Caged Protein Nanoparticles for Drug Delivery.” Current Opinion in Biotechnology. 28:75-82 (2014). Invited contribution for thematic issue on “Nanobiotechnology.”
A. Jabaiah, X. Wang, S. K. Raman, R. Ragan, N.A. Da Silva, S.-W. Wang. “Nanoscale Architecture and Cellular Adhesion of Biomimetic Collagen Substrates.” Journal of Biomaterials Applications.28(9):1354-1365 (2014).
D. Ren, F. Kratz, S.-W. Wang. “Engineered drug-protein nanoparticle complexes for folate receptor targeting.” Biochemical Engineering Journal. 89:33-41 (2014).
Invited contribution for special issue on “Bionanofabrication.”
N.M. Molino, A.K.L. Anderson, E.L. Nelson, S.-W. Wang. “Biomimetic Protein Nanoparticles Facilitate Enhanced Dendritic Cell Activation and Cross-Presentation” ACS Nano. 7:9743-9752 (2013).
S.W.P. Chan, J. Greaves, N. Da Silva, S.-W. Wang. “Assaying Proline Hydroxylation in Recombinant Collagen Variants by Liquid Chromatography-Mass Spectrometry,” BMC Biotechnology. 12:51 (2012). DOI: 10.1186/1472-6750-12-51
D. Ren, M. Dalmau, A. Randall, M.M. Shindel, P. Baldi, S.-W. Wang. “Biomimetic Design of Protein Nano-Carriers for Hydrophobic Molecular Transport.” Advanced Functional Materials. 22:3170-3180 (2012). Highlighted in Materials Views (www.materialsview.com on April 24, 2012)
M.M. Shindel, S.-W. Wang, A. Mohraz. “Interfacial Polymer Phase Segregation and Self-Assembly of Square Colloidal Crystals.” Soft Matter. 8:6684-6688 (2012).
X. Wang, M. Shindel, S.-W. Wang, R. Ragan. “Elucidating Driving Forces for Liposome Rupture: External Perturbations and Chemical Affinity.” Langmuir. 28:7417-7427 (2012).
N.M. Molino, K. Bilotkach, D.A. Fraser, D. Ren, S.-W. Wang. “Complement Activation and Cell Uptake Responses Toward Polymer-Functionalized Protein Nanocapsules.” Biomacromolecules. 13(4):974-981 (2012)
M. Shindel, D. Mumm, S.-W. Wang. “Manipulating Energy Landscapes to Tune Ordering in Biotemplated Nanoparticle Arrays .” Langmuir. 27(12):7768-7775 (2011).
D. Ren, F. Kratz, S.-W. Wang. “Protein Nanocapsules Containing Doxorubicin as a pH-Responsive Delivery System.” Small. 7(8):1051-1060 (2011).
X. Wang, M. Shindel, S.-W. Wang, R. Ragan. “A Facile Approach for Assembling Lipid Bilayer Membranes on Template-Stripped Gold,” Langmuir. 26(23):18239-18245 (2010).
S.W.P. Chan, S.-P. Hung, S. Raman, G.W. Hatfield, R. Lathrop, N. A. Da Silva., S.-W. Wang. “Recombinant Human Collagen and Biomimetic Variants Using a De Novo Gene Optimized for Modular Assembly.” Biomacromolecules. 11(6):1460-1469 (2010).
M. Shindel, D. Mumm, S.-W. Wang. “Biotemplating of Metallic Nanoparticle Arrays Through Site-Specific Electrostatic Adsorption on Streptavidin Crystal.” Langmuir. 26(11):11103-11112(2010).
M. Dalmau, S. Lim, S.-W. Wang. “pH-Triggered Disassembly in a Caged Protein Complex.” Biomacromolecules. 10(12):3199-3206 (2009). Featured in “Research Highlights” of Biopolymers (Vol. 93, no. 2, 2010)
M. Dalmau, S. Lim, S.-W. Wang. “Design of a pH-Dependent Molecular Switch in a Caged Protein Platform.” Nano Letters. 9(1):160-166 (2009).
M. Shindel, A. Mohraz, D. Mumm, S.-W. Wang. “Modulating Colloidal Adsorption on a Two-Dimensional Protein Crystal.” Langmuir. 25(2):1038-1046 (2009).
M. Dalmau, S. Lim, H. C. Chen, C. Ruiz, S.-W. Wang. “Thermostability and Molecular Encapsulation within an Engineered Caged Protein Scaffold.” Biotechnology and Bioengineering. 101(4):654-664 (2008). Highlighted in B&B’s “Spotlight” Feature and in December 2008 cover photo.
C. Lou, M. Shindel, L. Graham, S.-W. Wang. “Molecular Self-Assembly of Solid-Supported Protein Crystals.” Langmuir. 24(15):8111-8118 (2008).
C. Lou, Z. Wang, S.-W. Wang. “Two-Dimensional Protein Crystals on a Solid Substrate: Effect of Surface Ligand Concentration.” Langmuir. 23(19):9752-9759 (2007).
S.-W. Wang, J. Monagle, C. McNulty, D. Putnam, H. Chen. “Determination of P-glycoprotein Inhibition by Excipients and Their Combinations Using an Integrated High-Throughput Process.” Journal of Pharmaceutical Sciences. 93(11):2755-2767 (2004).
C.R. Gardner, O. Almarsson, H. Chen, S. Morissette, M. Peterson, Z. Zhang, S. Wang, A. Lemmo, J. Gonzalez-Zugasti, J. Monagle, J. Marchionna, S. Ellis, C. McNulty, A. Johnson, D. Levinson, M. Cima. “Application of High Throughput Technologies to Drug Substance and Drug Product Development.” Computers and Chemical Engineering. 28:943-953 (2004).
S.J. Farah, S.-W. Wang, W.-H. Chang, C.R. Robertson, A.P. Gast. “Point-Mutagenesis and Cocrystallization of Wild-Type and Mutant Proteins: A Study of Solid-Phase Coexistence in Two-Dimensional Protein Arrays.” Langmuir. 17(19):5731-5735 (2001).
S.-W. Wang, C.R. Robertson, A.P. Gast, S. Koppenol, T. Edwards, V. Vogel, P. Stayton. “Role of N- and C-Terminal Amino Acids in 2D Streptavidin Crystal Formation.” Langmuir. 16(11):5199-5204 (2000).
S.-W. Wang, C.R. Robertson, A.P. Gast. “Two-Dimensional Crystallization of Streptavidin Mutants.” The Journal of Physical Chemistry B. 103(37):7751-7761 (1999). (Invited feature article & Cover Picture)
S.-W. Wang, C.R. Robertson, A. P. Gast. “Molecular Arrangement in Two-Dimensional Streptavidin Crystals.” Langmuir. 15(4):1541-1548 (1999).
A. P. Gast, C. R. Robertson, S.-W. Wang, M. T. Yatcilla. “Two-Dimensional Streptavidin Crystals: Macropatterns and Micro-organization.” Biomolecular Engineering. 16(1-4): 21-27 (1999).
S.-W. Wang, C.L. Poglitsch, M.T. Yatcilla, C.R. Robertson, A.P. Gast. “Solid-Phase Coexistence in Chiral Domains of 2D Streptavidin Crystals.” Langmuir. 13(22):5794-5798 (1997). (Cover Picture)
C. Khosla, R. Caren, C.M. Kao, R. McDaniel, S.-W. Wang. “Evolutionally Guided Enzyme Design.” Biotechnology and Bioengineering. 52(1):122-128 (1996).