Co-expression of the TdTomato reporter and endogenous CRH in a transgenic mouse. (IRES-CRH-Cre mated with a TdTomato reporter mouse).
Using decoy oligonucleotides to inhibit NRSF function following an epilepsy-inciting event, we found that NRSF (a protein that stops cells from becoming neurons) contributes to epilepsy development by inhibiting a specific group of genes critically important for neuronal function like HCN1 and GRIN2A.
Chronic early-life stress (CES) induces decrease in the volume of dorsal hippocampus sub-regions involved in learning and memory in rats. 3-dimensional rendering of hippocampus from each group (CES & Control (CTL) illustrates reduced dorsal hippocampal volume