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2019

Short AK, Baram, TZ, Adverse early-life experiences and neurologic disease: Age-old questions and novel answers. Nat Rev Neuro. 2019. (in press)

Itoga, C, Chen Y, Short AK, Baram TZ, Xu, X. New viral-genetic mapping uncovers an enrichment of CRH-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions. J Comp Neurol (2019)

Jiang S, Kamei N, Bolton JL, Ma X, Stern HS, Baram TZ, Mortazavi A. Intra-individual methylomics detects the impact of early-life adversity. Life Sci Alliance. 2019. pii: e201800204. doi: 10.26508/lsa.201800204

Glynn LM, Stern HS, Howland MA, Risbrough VB, Baker DG, Nievergelt CM, Baram TZ, Davis EP. Measuring novel antecedents of mental illness: the Questionnaire of Unpredictability in Childhood. Neuropsychopharmacology. 2019. 44:876-882

 

2018

Bolton JL, Molet J, Regev L, Chen Y, Rismanchi N, Haddad E, Yang DZ, Obenaus A, Baram TZ. Anhedonia following early-life adversity involves aberrant interaction of anxiety and reward circuits and is reversed by partial silencing of amygdala corticotropin-releasing hormone. Biol Psychiatry, 2018, 83:137-147.

Singh-Taylor A, Molet J Jian S, Korosi A, Bolton JL, Noam Y, Simeone K, Cope J Chen Y, Mortazavi A, Baram TZ. NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience. Mol Psychiatry, 2018 (IF ~15)

Sandman CA, Curran MM, Davis EP, Glynn LM, Head K, Baram TZ. Cortical Thinning and Neuropsychiatric Outcomes in Children Exposed to Prenatal Adversity: A Role for Placental CRH? Am J Psychiatry, 2018, 175:471-479. (IF ~15)

Curran MM, Haddad E, Patterson KP, Choy M, Dubé CM, Baram TZ, Obenaus A. Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic? Epilepsia. 2018. doi: 10.1111/epi.14561.

Baram TZ, Bolton JL. Parental smartphone use and children's mental outcomes: a neuroscience perspective. Neuropsychopharmacology. 2019 44:239-240. doi: 10.1038/s41386-018-0184-8.

 

2017

Patterson KP, Barry JM, Curran MM, Singh-Taylor A, Brennan G, Rismanchi N, Page M, Noam Y, Holmes GL, Baram TZ. Enduring memory impairments provoked by developmental febrile seizures are mediated by functional and structural effects of neuronal restrictive silencing factor. J Neurosci, 2017.

Davis EP, Stout SA, Molet J, Vegetabile B, Glynn LM, Sandman CA, Heins K, Stern H, Baram TZ. Exposure to unpredictable maternal sensory signals influences cognitive development across species. PNAS, 2017, 114:10390-10395.

Gunn BG, Baram TZ. Stress and Seizures: Space, Time and Hippocampal Circuits. Trends Neurosci. 2017. 40:667-679. doi: 10.1016/j.tins.2017.08.004.

Gunn BG, Cox CD, Chen Y, Frotscher M, Gall CM, Baram TZ, Lynch G. The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus. Cereb Cortex. 2017. 27:4182-4198. doi:10.1093/cercor/bhx103.

 

2016

Brennan GP, Dey D, Chen Y, Patterson KP, Magnetta E, Hall AM, Dube CM, Mei Y-T, Baram TZ. Dual and opposing roles of microRNA-124 in the generation of epilepsy are mediated through inflammatory and NRSF-dependent gene networks. Cell Reports, 2016, 14:2402-2412.

Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram TZ. Converging, synergistic actions of multiple stress hormones mediate enduring memory impairments after acute simultaneous stresses. J Neurosci, 2016.

Molet J, Heins K, Zhuo X, Mei YT, Regev L, Baram TZ, Stern H. Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome. Transl Psychiatry, 2016, e702.

Molet J, Maras PM, Kinney-Lang E, Harris NG, Rashid F, Ivy AS, Solodkin A, Obenaus A, Baram TZ. MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity. Hippocampus, 2016, 26:1618-1632.

Chen Y, Baram TZ. Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks. Neuropsychopharmacology. 2016 41:197-206. doi: 10.1038/npp.2015.181.

 

2015

Patterson KP, Brennan GP, Curran M, Kinney-Lang E, Dubé C, Rashid F, Ly C, Obenaus A, Baram TZ. Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis. eNeuro. 2015

Chen Y, Molet J, Gunn BG, Ressler K, Baram TZ. Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons. Endocrinology. 2015 156:4769-80. doi:10.1210/en.2015-1673.

 

2014

Maras PM, Molet J, Chen Y, Rice C, Ji SG, Solodkin A, Baram TZ. Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress. Mol Psychiatry,19:811-822, 2014.

McClelland S, Brennan GP, Dubé C, Rajpara S, Iyer S, Richichi C, Bernard C, Baram TZ. The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes. Elife. 2014 doi: 10.7554/eLife.01267.

 

2013

Andres AL, Regev L, Phi L, Seese RR, Chen Y, Gall CM, Baram TZ. NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci. 2013 33(43):16945-60. doi:10.1523/JNEUROSCI.1445-13.2013.

Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M,Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013.   doi: 10.1038/nn.3359.

Chen Y, Kramár EA, Chen LY, Babayan AH, Andres AL, Gall CM, Lynch G, Baram TZ. Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry. 2013.

 

2012

Baram TZ, Davis EP, Obenaus A, Sandman CA, Small SL, Solodkin A, Stern H.Fragmentation and unpredictability of early-life experience in mental disorders.  Am J Psychiatry. 2012 169:907-15.

Chen Y, Andres AL, Frotscher M, Baram TZ. Tuning synaptic transmission in the hippocampus by stress: the CRH system. Front Cell Neurosci. 2012 Apr 3;6:13. doi: 10.3389/fncel.2012.00013

Maras PM, Baram TZ. Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 2012 35:315-24. doi: 10.1016/j.tins.2012.01.005.

 

2011

Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat Rev Neuro, 2011, 7:31-40.

McClelland S, Flynn C, Dubé C, Richichi C, Zha Q, Ghestem A, Esclapez M, Bernard C, Baram TZ. Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide-gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol. 2011 70:454-64.

Noam Y, Bernard C, Baram TZ. Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol. 2011 21(6):873-9. doi:10.1016/j.conb.2011.06.013

 

2010

Chen Y, Rex CS, Rice CJ, Dubé CM, Gall CM, Lynch G, Baram TZ. Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. PNAS, 29:13123-28, 2010.

Ivy A, Rex C, Chen Y, Dubé C, Maras P, Grigoriadis D, Gall C, Lynch G, Baram TZ. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve activation of CRH receptors. J Neurosci, 30:13005-15, 2010.

Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010 68:314-9. doi:10.1016/j.biopsych.2010.05.028.

Dubé CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, Andres AL, Nalcioglu O, Obenaus A, Vezzani A, Baram TZ. Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci. 2010 doi: 10.1523/JNEUROSCI.0551-10.2010

Korosi A, Shanabrough M, McClelland S, Liu ZW, Borok E, Gao XB, Horvath TL, Baram TZ. Early-life experience reduces excitation to stress-responsive hypothalamic neurons and re-programs the expression of CRH. J Neurosci, 2010, 30:703-713

Noam Y, Zha Q, Phan L, Wu RL, Chetkovich DM, Wadman WJ, Baram TZ. Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem. 2010 285:14724-36.

 

2009

Joëls M, Baram TZ. The Neuro-symphony of Stress. Nature Reviews Neuroscience,10:459-66, 2009 (cited > 1000 times)

 

2008

Rice CJ, Sandman CA, Lenjavi MR, Baram TZ. A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology. 2008.

Chen Y, Dubé CM, Rice CJ, Baram TZ. Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci. 2008.

 

2007

Dubé CM, Brewster AL, Richichi C, Zha Q, Baram TZ. Fever, febrile seizures and epilepsy. Trends Neurosci. 2007

Bender RA, Kirschstein T, Kretz O, Brewster AL, Richichi C, Shigemoto R, Beck H, Frotscher M, Baram TZ. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci. 2007

Brewster AL, Chen Y, Bender RA, Yeh A, Shigemoto R, Baram TZ. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cereb Cortex. 2007

 

2006

Fenoglio KA, Chen Y, Baram TZ. Neuroplasticity of the hypothalamic-pituitary-adrenal axis early in life requires recurrent recruitment of stress-regulating brain regions. J Neurosci. 2006 26:2434-42.

Dubé C, Richichi C, Bender RA, Chung G, Litt B, Baram TZ. Temporal lobe epilepsy after experimental prolonged febrile seizures: a prospective analysis. Brain. 2006

 

2005

Brunson KL, Kramár E, Lin B, Chen Y, Colgin LL, Yanagihara TK, Lynch G, Baram TZ. Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci. 2005

Dubé C, Vezzani A, Behrens M, Bartfai T, Baram TZ. Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol. 2005

 

2004

Chen Y, Bender RA, Brunson KL, Pomper JK, Grigoriadis DE, Wurst W, Baram TZ. Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. PNAS. 2004 101:15782-7.

 

2003

Santoro B, Baram TZ. The multiple personalities of h-channels. Trends Neurosci. 2003.

Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci. 2003

Sullivan PG, Dubé C, Dorenbos K, Steward O, Baram TZ. Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol. 2003

 

2002

Brewster A, Bender RA, Chen Y, Dube C, Eghbal-Ahmadi M, Baram TZ. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci. 2002

Avishai-Eliner S, Brunson KL, Sandman CA, Baram TZ. ‘Stressed out?’ Or in (utero). Trends Neurosci, 25:518-24, 2002

 

2001

Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nature Med. 2001

Chen Y, Bender RA, Frotscher M, Baram TZ. Novel and transient populations of corticotropin-releasing hormone-expressing neurons in developing hippocampus suggest unique functional roles: a quantitative spatiotemporal analysis. J Neurosci. 2001

Brunson KL, Eghbal-Ahmadi M, Bender R, Chen Y, Baram TZ. Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress. PNAS. 2001

Brunson KL, Khan N, Eghbal-Ahmadi M, Baram TZ. Corticotropin (ACTH) acts directly on amygdala neurons to down-regulate corticotropin-releasing hormone gene expression. Ann Neurol. 2001

 

1998-2000

Chen K, Baram TZ, Soltesz I. Febrile Seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nature Medicine, 1999, 5:888-894.

Chen Y, Brunson KL, Müller MB, Cariaga W, Baram TZ. Immunocytochemical distribution of corticotropin-releasing hormone receptor type-1 (CRF(1))-like immunoreactivity in the mouse brain: light microscopy analysis using an antibody directed against the C-terminus. J Comp Neurol. 2000

Dube C, Chen K, Eghbal-Ahmadi M, Brunson K, Soltesz I, Baram TZ. Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann Neurol. 2000

Baram TZ, Hatalski CG. Neuropeptide-mediated excitability: A key triggering mechanism for seizure generation in the developing brain. Trends Neurosci, 1998, 21:471-476.

 

Other notable work:

Baram TZ, Koch Y, Hazum E, Fridkin M. Gonadotropin-releasing hormone in milk. Science. 1977 198:300-2.

Baram TZ, Mitchell WG, Tournay A, Snead OC, Hanson RA, Horton EJ. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics,1996, 97:375-379. This study, cited >300 times, is the basis of FDA approval for high-dose ACTH for infant epilepsy.

Baram TZ, Goldman AM, Percy AK. Krabbe disease: specific MRI and CT findings. Neurology. 1986 36:111-5.