Gyorgy Lur, PhD

The primary goal of my research is to understand how neurons summate synaptic input from various modalities and how changes in the cells’ neurochemical environment regulate this integration. I am particularly interested in the interaction of feed forward pathways, carrying sensory input and feed-back circuits conveying contextual information.

I am utilizing a multi-level approach to uncover fundamental principles of signal integration. To probe the cellular and circuit mechanisms of synaptic summation my lab combines whole cell patch clamp electrophysiology with dual-color optogenetic stimulation in acute brain slices. Then, to test our predictions generated based on slice data we employ optical methods to measure and perturb neuronal activity during behavior.

I have a strong background in cell biology from working with Dr. Alexei Tepikin and Dr. Ole Petersen as a graduate student in the Department of Physiology at the University of Liverpool, UK. My PhD work focused on protein interactions regulating calcium release- and entry mechanisms in non-excitable cells. I then applied my expertise in cellular signaling to synaptic biology in the laboratory of Dr. Michael Higley at Yale Medical School. At Yale I expanded my skill-set with neurophysiology and state of the art optical techniques to observe and manipulate neuronal activity in vitro as well as in vivo. This training has provided me with a broad foundation ranging from molecular biology to systems neuroscience.  As an independent investigator, I focus on topics that not only expand our knowledge of the nervous system but also have the potential to benefit society at large via translational applications.