Cortical neurons can receive up to 10,000 synaptic inputs from dozens of different sources. How do these inputs integrate to generate neuronal firing? How does the local microcircuit and the cell’s neurochemical environment regulate the relative strength of the incoming synapses? How do changes associated with neuropsychiatric conditions, like chronic stress, erode the delicate balance of neuronal circuits and result in degrading cognitive performance? These are the questions we are exploring in the Neuronal Signal Integration Lab.