Publications

For the current list: Pubmed & Google Scholar

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In reverse chronological order (newest to oldest):

[2024]

• Pharmacological potential of cyclic nucleotide signaling in immunity. Ednacot EMQ, Nabhani A, Dinh DM, Morehouse BR. Pharmacology & Therapeutics. 2024; 258:108653. PMID: 38679204 [Review]

• An OLD protein teaches us new tricks: prokaryotic antiviral defense. Ednacot EMQ, Morehouse BR. Nature Communications. 2024; 15:2527. PMID: 38514789 [Comment]
  • Check out the original article from Huo et al., published in Nature Communications, to get the full story – Structural and biochemical insights into the mechanism of the Gabija bacterial immunity system

[2023]

• Say YES to single-gene lysis! Nabhani A, Morehouse BR. Cell Host & Microbe. 2023; 31(9):1420-1422. PMID: 37708847 [Preview]
  • Check out the original article from Orta et al., published in Science, to get the full story – The mechanism of the phage-encoded protein antibiotic from φX174

• cGLRs are a diverse family of pattern recognition receptors in innate immunity. Li Y, Slavik KM, Toyota HC, Morehouse BR, de Oliveira Mann CC, Elek A, Levy S, Wang Z, Mears K, Liu J, Kashin D, Guo X, Mass T, Sebé-Pedrós A, Schwede F, Kranzusch PJ. Cell. 2023; 186(15):3261-3276.e20. PMID: 37379839
  • See how the manuscript changed from the original preprint on bioRxiv
  • Check out the Research Highlights from Yvonne Gordon – Thousands of cGAS-like receptors described in animals
  • Check out the Preview from Leonie Unterholzner – Innate immune sensing by cGAS-STING in animals reveals unexpected messengers
  • Check out the Spotlight from Fiachra Humphries – cGAS-like receptors: back to the future

• Phage defense origin of animal immunity. Morehouse BR. Current Opinion in Microbiology. 2023; 73:102295. PMID: 37011504 [Review]
  • Part of special issue “Evolution of anti-viral defense”

[2022]

• Viruses inhibit TIR gcADPR signaling to overcome bacterial defense. Leavitt A*, Yirmiya E*, Amitai G*, Lu A*, Garb J, Herbst E, Morehouse BR, Hobbs SJ, Antine SP, Sun ZYJ, Kranzusch PJ†, Sorek R†. Nature. 2022; 611:326–331. PMID: 36174646 *contributed equally †co-corresponding

• Cryo-EM structure of an active bacterial TIR-STING filament complex. Morehouse BR, Yip MCJ, Keszei AFA, McNamara-Bordewick NK, Shao S†, Kranzusch PJ†. Nature. 2022; 608:803-807. PMID: 35859168  †co-corresponding

• Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ. Nature. 2022; 605:522-526. PMID: 35395152
  • Check out the News and Views from Urs Jenal – Killing the messenger to evade bacterial defences
  • Check out the Spotlight from Nils Birkholz & Peter Fineran – Turning down the (C)BASS: Phage-encoded inhibitors jam bacterial immune signaling

[2021]

• Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Tal N*, Morehouse BR*, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R. Cell. 2021; 184:5728–5739. PMID: 34644530 *contributed equally
  • Check out the Preview from Karen Maxwell – Cyclic pyrimidines jump on the anti-phage bandwagon
  • Check out the In Brief notice from Ursula Hofer – Cyclic pyrimidines defend against phages
  • Check out the Perspective from Roland Seifert- cCMP and cUMP come into the spotlight, finally

• cGAS-like receptors sense RNA and control 3’2′-cGAMP signaling in Drosophila. Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler J-L, Kranzusch PJ. Nature. 2021; 597(7874):109–113. PMID: 34261127
  • Check out the Research Highlight from Yao Fan, Long Zhang, and Fangfang Zhou – cGAS-like receptors: new RNA sensors in Drosophila
  • Check out the Spotlight from Taoyong Chen & Xuetao Cao – cGAS-like receptors: ancient catches of viral nucleic acids
  • Check out the News and Views from Cara West and Neal Silverman – cGAS-like receptors put a sting into the evolution of immune defence

[2020]

• STING cyclic dinucleotide sensing originated in bacteria. Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, Kranzusch PJ. Nature. 2020; 586(7829):429–433. PMID: 32877915
  • Check out the News and Views from Justin Jenson & James Chen – Bacteria sting viral invaders

• CBASS immunity uses CARF-related effectors to sense 3’–5′- and 2’–5′-linked cyclic oligonucleotide signals and protect bacteria from phage infection. Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. Cell. 2020; 182(1):38–49.e17. PMID: 32544385
  • Check out the Preview from Malcolm White – Bacteria SAVED from Viruses

[2019]

• Direct evidence of an enzyme-generated LPP intermediate in (+)-limonene synthase using a fluorinated GPP substrate analog. Morehouse BR*, Kumar RP*, Matos JO, Yu Q, Bannister A, Malik K, Temme JS, Krauss IJ†, Oprian DD†. ACS Chem Biol. 2019; 14(9):2035–2043. PMID: 31433159 *contributed equally †co-corresponding

• Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ†, Kranzusch PJ†. Nature. 2019; 567(7747):194–199. PMID: 30787435 †co-corresponding
  • Check out the Preview from Chris Waters – Pyrimidines and Cyclic Trinucleotides Join the Second Messenger Symphony

[2018]

• Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance. Zhou W*, Whiteley AT*, de Oliveira Mann, C. C., Morehouse BR, Nowak, RP, Fischer, ES, Gray, NS, Mekalanos JJ, Kranzusch, PJ. Cell. 2018; 174(2):300–311. PMID: 30007416 *contributed equally
  • Check out the Preview from Alexiane Decout & Andrea Ablasser – Human cGAS Has a Slightly Different Taste for dsDNA

[2017]

• Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. Kumar RP*, Morehouse BR*, Fofana J, Trieu MM, Zhou DH, Lorenz MO, Oprian DD. J Biol Chem. 2017; 29;292(52):21578–21589. PMID: 29118188 *contributed equally

• Structural characterization of early Michaelis complexes in the reaction catalyzed by (+)-limonene synthase from Citrus sinensis using fluorinated substrate analogues. Kumar RP*, Morehouse BR*, Matos JO, Malik K, Lin H, Krauss IJ, Oprian DD. Biochemistry. 2017; 56(12):1716–1725. PMID: 28272876 *contributed equally

• Functional and structural characterization of a (+)-limonene synthase from Citrus sinensis. Morehouse, BR*, Kumar, RP*, Matos, JO, Olsen, SN, Entova, S, Oprian, DD. Biochemistry. 2017; 56(12):1706–1715. PMID: 28272875 *contributed equally