Our TiNS review “Neurocognitive aging and the hippocampus across species” is now online. Here are some of the trends we discuss in the article:
- The role of neurogenesis in the dentate gyrus in the context of neurocognitive aging has been recently revisited, given data suggesting that neurogenesis continues into older adulthood.
- The lateral entorhinal and perirhinal cortices represent early sites of vulnerability in aging and age-related decline. Designing tasks and approaches to examine these extrahippocampal pathways is crucial
- Hyperexcitability in the hippocampal network is a key pathological state in the aging brain that confers risk for Alzheimer’s disease (AD), potentially linking AD and subclinical epilepsy.
- Epigenetic imaging (e.g., HDAC PET) is an emerging technology that will allow more detailed examinations of epigenetic changes related to memory decline in the aging human brain.