New review in Trends in Neurosciences

Our TiNS review “Neurocognitive aging and the hippocampus across species” is now online. Here are some of the trends we discuss in the article:

  1. The role of neurogenesis in the dentate gyrus in the context of neurocognitive aging has been recently revisited, given data suggesting that neurogenesis continues into older adulthood.
  2. The lateral entorhinal and perirhinal cortices represent early sites of vulnerability in aging and age-related decline. Designing tasks and approaches to examine these extrahippocampal pathways is crucial
  3. Hyperexcitability in the hippocampal network is a key pathological state in the aging brain that confers risk for Alzheimer’s disease (AD), potentially linking AD and subclinical epilepsy.
  4. Epigenetic imaging (e.g., HDAC PET) is an emerging technology that will allow more detailed examinations of epigenetic changes related to memory decline in the aging human brain.