May 2018: Congratulations to Xiantong Yang who’s presentation and abstract entitled “Time Lapse Phasor-FLIM Analysis of Huntington’s disease Inclusions” has been accepted for the 2018 UCI Undergraduate Research Symposium to be held Saturday, May 19, 2018, at the UCI Student Center

May 2018: Congratulations to Ning Ma and Team members of “Emlumination” for being accepted to the I-Corps (NSF funded program) for Entrepreneurship training!

May 2018: Congratulations to Linghao Kong for being chosen to be a Rabi Scholar at Columbia College.

April 10, 2018: Congratulations to Austin Lefebvre for being warded the NSF Graduate Research Fellowship Program Award! (GRFP)

April 2018: Welcome Anthony Tsai, rotation graduate student in the Dept. Chemical Engineering and Materials Sciences, to the lab!

April 2018: Welcome Daniel Hadraba, Visiting Scholar from FTVS, Charles University, Czech Republic, to the lab!

March 15, 2018: Congratulations to Sara Sameni for the successful defense of  her Thesis!

February 2018: Congratulations Emma on receiving the prestigious UCI AGS Travel Grant!

February 2018: Congratulations to Emma and Gabby for your archived file  title  “Collagen stiffness modulates MDA-MB231 cell metabolism through adhesion-mediated contractility” Emma J. Mah, Gabrielle E. McGahey, Albert F. Yee, Michelle A. Digman.

January 29, 2018:  Congratulations to Linghao Kong and Michael Murata on the publication as first co-authors for your work, Kong, L., Murata, M. M. & Digman, M. A. Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells. Biochem Biophys Res Commun 496, 199-204, doi:10.1016/j.bbrc.2018.01.026 (2018

January 19, 2018: Congratulations to the UROP Grant/Fellowship recipients: Stephanie M. Pascua, Gabrielle McGahey, Xiantong Yang and Siddharth Verma!!! All of our BME research undergraduates.

December 22, 2017: Congratulations to Sara Sameni on the publication as first author for your work, Sameni, S., Malacrida, L., Tan, Z. & Digman, M. A. Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. Scientific Reports 8, 734, doi:10.1038/s41598-018-19160-0 (2018).

December 6, 2017: Congratulations to Andrew Trinh on the publication as first author for your work, “Tracking Functional Tumor Cell Subpopulations of Malignant Glioma by Phasor Fluorescence Lifetime Imaging Microscopy of NADH”, Cancers 2017, 9(12), 168; doi:10.3390/cancers9120168

November 30, 2017: Congratulations to the Digman Lab for the work done by Emma Mah for funding from the  AMERICAN CANCER SOCIETY, INSTITUTIONAL RESEARCH GRANTS, for the project “Mitochondria Recruitment and Metabolism in Cancer Cells”.

July 2017: Congratulations to the Digman Lab for funding from the The Gordon and Betty Moore Foundation: 2017 Scialog: Molecules Come to Life conference ”Follow the leader: forecasting collective cancer dynamics”

June 30, 2017: Congratulations Sara Sameni for winning a Poster Presentation Award at the 2017 18th Annual UC Systemwide Bioengineering Symposium hosted at UCLA!



June 20, 2017: Congratulations Andrew Trinh for advancing to Ph.D. candidacy!

June 20, 2017: Congratulations to Gabrielle McGahey for the Undergraduate Research Opportunities Program (UROP) grant and Summer Undergraduate Research Program (SURP) award!

June 15, 2017: Congratulations to Prof. Digman on receiving a Hellman Fellows award!

June 16, 2017: Prof. Digman was invited to be Plenary Speaker, Ontario Networking Event (ONE) in Biophysics, “Frontiers in Image Correlation Microscopy:Mapping diffusive routes of single  proteins in living cells” University of Toronto Mississauga.

June 11-15, 2017: Prof. Digman was invited to be a Lecturer for the “Advanced microscopy – physical concepts and impacts in life sciences” Physics School, Sponsored by the German Physical Society,June 11 – 16, 2017, in Bad Honnef, Germany.

May 23, 2017: Congratulations to Sara Sameni who has been awarded the President’s Dissertation Year Fellowship Program for the 2017-2018 Academic year.

April 24, 2017: Congratulations to Linghao Kong for winning 3rd place award in the biochemistry molecular biology, at the OC Science fair OCSEF and a special award though the AACC (American Association for Clinical Chemistry) !

April 5, 2017: Congratulations to Dr. Jenu Chacko for your new position at the Eliceiri/LOCI lab! We wish you the best in your future endeavors!

March 16, 2017: Prof. Digman was invited to give a talk titled “Frontiers in Fluctuation Spectroscopy: Measuring protein dynamics and protein spatio-temporal connectivity” at the American Physical Society Meeting (APS) in the “Multiscale Physics of Cellular Remodeling” Session.

March, 2017: Congratulations to Neal Sharma for winning a special award from the American Association of Clinical Chemistry!


January 27, 2017: Congratulations to Sara Sameni for winning 1st Place at the14th  Advanced Imaging Methods Workshop (AIM), University of California Berkeley.


January 16, 2017: Congratulations to Emma Mah and Elena Liang on the publication as first co-authors for your work, “Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography”, Integr. Biol., 2017, Advance Article.DOI: 10.1039/C6IB00193A

December 12, 2016: Prof. Digman was invited be a seminar speaker at University of Oxford, Division of Structural Biology, talk title: “Spatial-temporal imaging methods and fluorescence lifetime analysis to measure p53 protein dynamics in living cells”.

November 22, 2016: Congratulations Sara Sameni for obtaining the 2016-2017 Public Impact Fellowship, which is “intended to support and highlight academically excellent students whose research demonstrates the potential to significantly improve or enrich the lives of people in California and beyond.”

From the Samueli School of Engineering news:

October 7, 2016: Congratulations Sara Sameni for publishing your work: “The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease”, Scientific Reports,  6, Article number: 34755 (2016) doi:10.1038/srep34755.

September 2016: Fluorescence Dynamics Laboratory Celebrates 30 Years of NIH Funding:

UC Irvine’s Llfd-digman-and-gratton-for-webaboratory for Fluorescence Dynamics (LFD) has received a five-year, $7.2 million operating grant from the National Institutes of Health (NIH). This marks the 30th year of NIH funding for the lab, the country’s only national research center dedicated to fluorescence.

August 2016: NEWS St. Margaret’s- Samueli School summer internship program
.The Digman Lab’s participation

August 23, 2016: Congratulations Michael Murata for advancing to Ph.D. candidacy!

August 1, 2016: Congratulations to the Laboratory for Fluorescence Dynamics for 5 more years of funding! National Institutes of Health: 8P41GM103540

Join us for celebrating: Frontiers in Biological Fluorescence 2016
A symposium celebrating Enrico Gratton’s 70th birthday and 30 years of the Laboratory for Fluorescence Dynamics. Friday, September 30, 2016, University of California, Irvine

July 27, 2016: Congratulations Ning Ma for advancing to Ph.D. candidacy!

June 21, 2016: Congratulations Jenu Chacko (Digman lab) and Anerudh Kannan (Siryaporn Lab) for receiving the CCBS  “Opportunity Award” for your project entitled: “Metabolic profiling of bacterial persister cell formation and virulence activation”.

May 23, 206: Dr. Digman received the Faculty Innovation in Teaching award which was presented at the SSoE Spring Faculty & 3rd Annual Spring Faculty Awards Meeting.

May 12, 2016: Congratulations Sara Sameni for advancing to Ph.D. candidacy!

May 6, 2016: Congratulations to our undergraduate team “Embrylux”: Tiffany Chien, Shinnosuke Fukazawa, Thai Nguyen, Daniel D. Tran, and Yingkai Su, for winning first place in two categories in the 2016 Business Plan Competition

  • First place at the 2016 Business Plan Competition at The Paul Merage School of Business in the Life Sciences division!
  • First Place in the Life Tech Surge competition!
  • Embrylux2


May 3, 2016: Congratulations to Justin Wang for receiving the Chapman Young Innovator Award!

April 2016: Congratulations to Justin Wang for Winning 1st place in pharmacology at the California State Science Fair!

March 2016: 2016 Intel ISEF Semifinalists Announced: Congratulations to Justin Wang and Neal Sharma! Two of our High School Students.

March 9, 2016: Congratulations Emma Mah for advancing to Ph.D. candidacy!

2016 Congratulations to 2016 UROP Fellows at UCI for the 2015-2016 academic year (all undergraduates in our lab)!
Tiffany Chien, Daniel D. Tran, Yingkai Su, Shinnosuke Fukazawa, Thai Nguyen

Feb. 27, 2016 Prof. Michelle Digman was nominated by the Biophysical Society members to be the 2018 subgroup chair in Biological Fluorescence.

2015 Congratulations to our 2015 BEST (Biophotonics across Energy, Space, and Time) IGERT Fellows: Sara Sameni and  Andrew Trinh

Grants awarded 2015-2016:

R01 AI117061 NIH/NIAID    W.Zhao (PI)       Digman, Gratton, Huang, Peterson (Co-PI)
Title: “Integrated Comprehensive Droplet Digital Detection (IC 3D) System for Rapid Detection of Bacteria and Antimicrobial Resistance”
Total Award Period Covered: 04/01/15 – 03/31/20
Total: $945,100
Purpose: We aim to develop an integrated comprehensive droplet digital detection (IC 3D) high throughput device based on a 3D particle counter to rapidly analyze unprocessed patient blood of 1-5 mls.
1R25HG008875-01 (MPI) Charless Fowlkes (MPI) and Michelle Digman (MPI)
Title: The Big DIPA: Data Image Processing and Analysis.
Total Award Period Covered:  09/30/2016-06/30/2019
Total: $486,000
Purpose: This proposal aims to establish a national short course in Big Data Image Processing & Analysis (BigDIPA) intended to increase the number and overall skills of competent research scientists now encountering large, complex image data sources derived from cutting edge biological/biomedical research approaches. The course will be offered this fall following the LFD workshop. See for more details.
UCI Multi Investigator Innovation Grant (CORCL)    G.Abbott (PI) & M.Digman (PI)
Title:  Subunit Dynamics in Cardiac Potassium Channel Complexes
Total Award Period Covered: 7/2015-6/2016
Total: $10,000
Major Goals: This is an incentive grant to provide preliminary data for understanding the regulation of KCNQ1 potassium ion channel by KCNE family regulatory subunits using dynamic imaging technologies. Using the raster image correlation spectroscopy and TIRF imaging to measure the mean square displacement we can distinguish between KCNE subunits binding/unbinding from channel complexes within the cells, versus whole channel complexes appearing in the membrane de novo.
ICTS Funding: 2015 ICTS Pilot Funding Phase II H. Luecke (PI) M.Digman (CoPI)
Title: Understanding how lead compounds reactivate p53 cancer mutant function using novelbiochemical and biophysical techniques
Total Award Period Covered: 9/2015-9/2016
Total: $30,000
Major Goals: To develop an innovative pharmaceutical that targets mutant p53 DBD to restore its wild-type functionality using dynamic imaging techniques. The techniques used in this proposal called number and molecular brightness (N&B) analysis, can measure p53 tetramerization in real time and space. Thereby allowing us to detect protein activity in localized regions of the nucleus.

Center for Advanced Design & Manufacturing of Integrated Microfluidics (CADMIM) Project Leaders: A.Lee (UCI) & C.Ahn (UC), M.Digman (UCI)
Title: Droplet-based single cell assays – from phenotype to genotype
Total Award Period Covered:  2/2016-2/2017
Total: $80,000
Major Goals: To use the powerful droplet platform to correlate the phenotype of cells with the genotype of cells with the two aforementioned droplet technology advancements. Both technologies utilize existing standard droplet microfluidics configurations to ensure that if successful, the techniques can be widely adopted by the field.

2015 New Publication: “Spectral properties and dynamics of gold nanorods revealed by EMCCD-based spectral phasor method.” Microsc. Res. Tech. 2015 Feb 13. Epub 2015 Feb 13.

March 4, 2015 Congratulations to  Hari and Anita Garg for winning the blue ribbon in this year’s Unified School District Science Fair and receiving the Irvine Ranch Water District Award! They are both our high school students who also participated in our 2012, 2013, & 2014 outreach program!

March 4, 2015 Congratulations to Justin Wang for winning a blue ribbon in  this year’s Unified School District Science Fair! He is a high school students who also participated in our 2013 & 2014 outreach program!

Sept. 10, 2014 Congratulations to Emma Mah for receiving a NSF BEST IGERT research trainee-ship!

Jun. 16, 2014 Congratulations to Joshua Yu for being the recipient of the Undergraduate Research Program (SURP) fellowship!

Biomedical Engineer Receives Grant from Allergan:
“Allergan has awarded Michelle Digman a $787,000 grant to study how a subunit of botulinum neuro-toxin affects cells and tissue on a molecular level.”

UC Irvine stem cell researchers awarded $1.54 million in state funding:
…”Donovan and fellow UC Irvine researchers Marian Waterman, Robert Edwards and Michelle Digman will use a $540,000 grant for a new kind of microscopy to capture images of the metabolic states of cells in living tissue in order to identify stem cell populations.”

Featured in UCI’s BME Discovery 2014 News Letter:
Digman Uses Fluorescent Imaging to Study Ebola Virus Protein

Biophysical Tools Key to Understanding How Ebola Spreads:

Shedding (fluorescent) Light on Ebola: UCI team uses novel technique to track key protein in deadly virus.

UCI is waging an Ebola battle that might lead to cure:

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