Nabil and Alli’s study showing that inhibition of the CSF1R at sub-microglial lethal levels can prevent chemotaxis of microglia to plaques, was published in the Journal of Neuroinflammation. This results in a lack of microglia associating with plaques and improves cognition in AD mice.
Colony stimulating factor 1 receptor inhibition prevents plaque-associated microglia and improves cognition in 3xTg-AD mice.
Dagher NN*, Najafi AR*, Neely Kayala KM, Elmore MRP, White T, Medeiros R, West BL, and Green KN. Journal of Neuroinflammation. 2015, 12:139