Lindsay Hohsfield, Ph.D.

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Lindsay graduated from the University of Colorado at Boulder in 2007 with a BA in Molecular, Cellular, and Developmental Biology. She then received an NIH Postbaccalaureate IRTA and worked in the TSE/Prion Cell Biology Section at the NIAID Rocky Mountain Laboratories until 2009. Following this, Lindsay was awarded a Fulbright grant to pursue Alzheimer’s research in Austria. She stayed on to continue her research and graduated from the Medical University of Innsbruck in 2014 with a PhD in Neuroscience. At UC Irvine, Lindsay will continue her work on Alzheimer’s disease trying to better understand how the immune system plays a role in neurodegenerative diseases. Lindsay’s hobbies include climbing, hiking, drawing, cuddling with her cute Husky Kaia, and speaking with an Austrian accent.

Contact: lhohsfie@uci.edu

Publications

Hohsfield LA, Humpel C. Intravenous infusion of monocytes isolated from 2-week-old mice enhances clearance of Beta-amyloid plaques in an Alzheimer mouse model. PLoS One. 2015 Apr 1;10(4):e0121930.

Hohsfield LA, Humpel C. Migration of blood cells to b-amyloid plaques in Alzheimer’s disease. Experimental Gerontology, 2015 May;65:8-15.

Hohsfield LA, Daschil N, Orädd G, Strömberg I, Humpel C. Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer’s disease mouse models. Molecular and Cellular Neuroscience. 2014 Nov;63: 83-95.

Hohsfield LA, Ehrlich D, Humpel C. Intravenous infusion of nerve growth factor-secreting monocytes supports the survival of cholinergic neurons in the nucleus basalis of Meynert in hypercholesterolemia Brown-Norway rats. Journal of Neuroscience Research. 2014 Mar;92(3):298-306.

Hohsfield LA, Ehrlich D, Humpel C. Cholesterol diet counteracts repeated anesthesia/infusion-induced cognitive deficits in male Brown Norway rats. Neurobiology of Learning and Memory. 2013 Nov;106:154-62.

Taguchi Y, Hohsfield LA, Hollister JR, Baron GS. Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning. ChemBioChem. 2013 Sep 2;14(13):1597-610, 1510.

Hohsfield LA, Ammann CG, Humpel C. Inflammatory status of transmigrating primary rat monocytes in a novel perfusion model simulating blood flow. Journal of  Neuroimmunology. 2013 May 15;258(1-2):17-26.

Hohsfield LA, Geley S, Reindl M, Humpel C. The generation of NGF-secreting primary rat monocytes: a comparison of different transfer methods. Journal of Immunological Methods. 2013 May 31;391(1-2):112-24.

Hochstrasser T*, Hohsfield LA*, Sperner-Unterweger B, Humpel C. β-Amyloid induced effects on cholinergic, serotonergic, and dopaminergic neurons is differentially counteracted by anti-inflammatory drugs. Journal of Neuroscience Research. 2013 Jan;91(1):83-94.

Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD. Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans. Autophagy. 2007 Nov-Dec;3(6):569-80.